Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
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BackgroundCXC chemokine receptor 4 (CXCR4) is associated with the progression and metastasis of numerous malignant tumors.However, its relationship with Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 (GEP-NENs G3) is unclear.The aim of this study was to characterize the expression of CXCR4 in GEP-NENS and to explore the clinical and prognostic value of CXCR4.
MethodsThis study retrospectively collected clinical and pathological data from patients with GEP-NENs who receiving surgery in Qilu Hospital of Shandong University from January 2013 to April 2021, and obtained merlin wizard costume the overall survival of the patients based on follow-up.Immunohistochemistry (IHC) was performed on pathological paraffin sections to observe CXCR4 staining.Groups were made according to pathological findings.
Kaplan-Meier (K-M) curve was used to evaluate prognosis.SPSS 26.0 was used for statistical analysis.
Results100 GEP-NENs G3 patients were enrolled in this study.There was a significant difference in primary sites (P=0.002), Ki-67 index (P<0.
001), and Carcinoembryonic Antigen (CEA) elevation (P=0.008) between neuroendocrine tumor (NET) G3 and neuroendocrine carcinoma (NEC).CXCR4 was highly expressed only in tumors, low or no expressed in adjacent tissues (P<0.
001).The expression level of CXCR4 in NEC was significantly higher than that in NET G3 (P=0.038).
The K-M curves showed that there was no significant difference in overall survival between patients with high CXCR4 expression and patients with low CXCR4 expression, either in GEP-NEN G3 or NEC (P=0.920, P=0.842.
respectively).ConclusionDifferential expression of CXCR4 was found between tumor and adjacent tissues and between NET G3 and NEC.Our results demonstrated that CXCR4 can be served as a new IHC diagnostic indicator in the diagnosis and differential diagnosis click here of GEP-NENs G3.
Further studies with multi-center, large sample size and longer follow-up are needed to confirm the correlation between CXCR4 expression level and prognosis.